Development and validation of an MRI-based radiomics nomogram to predict progression-free survival in patients with endometrial cancer

Motivation: There is no appropriate index to assess the prognosis of patients with endometrial cancer after surgery. Goal(s): Our goal was to explore the value of an MRI-based radiomics nomogram in predicting the progression-free survival (PFS) of patients with endometrial cancer. Approach: A nomogram was established using multivariable Cox regression by incorporating significant clinical-pathological predictors and radiomics signatures developed by another least absolute shrinkage and selection operator Cox regression. Results: The nomogram proved itself valuable in predicting PFS. Furthermore, the radiomics nomogram–defined risk stratification was associated with PFS. Impact: The novel nomogram may contribute to the precise stratification of patients with a high risk of progression. Therefore, more active follow-up and adjuvant therapy should be carried out after surgery to prolong and improve the patients' quality of life.