Highly under-sampled 3D Dynamic Hyperpolarized 13C Spiral Chemical Shift Imaging with Low Rank Plus Local Sparse Reconstruction

Motivation: Fully sampled 3DspCSI acquisition limits the temporal resolution for dynamic imaging Goal(s): Our goal was to reconstruct highly under-sampled 3DspCSI without significant image artifactsApproach: We proposed a low rank plus local sparse (LLS) reconstruction with two types of configurations to reconstruct the under-sampled 3DspCSI dataResults: proposed methods with both types of configurations can effectively reduce the image artifacts due to under-sampling. Type 2 configuration performs slightly better than Type 1 with less image artifacts due to the distinct patterns along the slice dimensionImpact: With the proposed LLS reconstruction, an effective acceleration of 4 can be achieved for 3DspCSI without significant image artifacts. The improvement in temporal resolution helps to quantify the metabolite kinetics during a fixed imaging window with hyperpolarized 13C agents