Fast repeated administrations of PHIP hyperpolarized [1-13C]pyruvate enables averaging of in vivo metabolism in a single MRI exam
Motivation: Parahydrogen Induced Polarization (PHIP) is a potential alternative to d-DNP for the polarization of [1-13C]pyruvate, but has so far been limited to low polarizations, low concentrations, and high impurities. Goal(s): We present, for the first time at a conference, recent advances in the polarization of [1-13C]pyruvate using PHIP via Side-Arm-Hydrogenation. Approach: Demonstration of an automated production of hyperpolarized [1-13C]pyruvate using PHIP-SAH. The PHIP system was benchmarked against a d-DNP system and hyperpolarized [1-13C]pyruvate from both systems was injected in animals for comparative in vivo metabolic MRI. Results: PHIP and d-DNP based hyperpolarization achieve comparable results, but PHIP is much faster. Impact: PHIP is demonstrated as a fast, effective, and cost-efficient polarization method for [1-13C]pyruvate. With very short dose production times, researchers are enabled to administer multiple (4) injections into the same animal within reasonable anesthesia time (<1h), allowing averaging of metabolism.
Authors
- Senay Karaali
- John W. Blanchard (ORCID: https://orcid.org/0000-0002-1621-6637)
- Michael Keim
- Sebastian Lucas
- Jochen Scheuer
- Christophoros C. Vassiliou
- Wolfgang Gottwald (ORCID: https://orcid.org/0009-0002-3779-7087)
- Geoffrey J. Topping
- Martin Grashei (ORCID: https://orcid.org/0000-0002-5019-9359)
- Christoph Müller (ORCID: https://orcid.org/0000-0002-6798-5487)
- Felix Josten
- Sandra Sühnel
- Luca Nagel (ORCID: https://orcid.org/0000-0002-5530-6264)
- Martin Gierse (ORCID: https://orcid.org/0000-0002-8187-5903)
- Franz Schilling (ORCID: https://orcid.org/0000-0001-5239-4628)
- Frits H. A. van Heijster (ORCID: https://orcid.org/0000-0002-0814-5189)
- Stephan Knecht (ORCID: https://orcid.org/0000-0002-8487-4324)
- Jonas Handwerker (ORCID: https://orcid.org/0000-0002-6098-051X)
- Ilai Schwartz (ORCID: https://orcid.org/0009-0001-5621-859X)
- Pascal Wolff
- Andre Wendlinger (ORCID: https://orcid.org/0009-0003-2056-8752)
- Nadine Setzer
- Zumrud Ahmadova
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3065
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00