Whole-cerebrum guanidino and amide CEST mapping at 3T by 3D EPI GRE and 3D stack-of-spiral GRE acquisitions
Motivation: We are driven by the critical need to efficiently map guanidino and amide CEST in the human brain at 3T, enabling the investigation of brain creatine and protein while adhering to clinical scan time constraints. Goal(s): Our aim is to validate the efficacy of 3D EPI GRE and 3D stack-of-spiral (3DSOS) GRE techniques for rapid guanidino and amide CEST mapping at 3T. Approach: We optimized saturation parameters, conducted a comparative analysis of SNR and reproducibility, and demonstrated 3DSOS in a low-grade glioma patient. Results: Both techniques yielded similar CEST signal intensities, with 3DSOS showing superior reproducibility. Impact: While 3DEPI and 3DSOS yielded similar signal intensity in whole-cerebrum guanidino and amide CEST mappings at 3T, the latter is recommended for clinical application with its enhanced reproducibility and showed an increase of guanidino CEST in the tumor.
Authors
- Lindsay Blair (ORCID: https://orcid.org/0000-0001-7335-4537)
- David Kamson (ORCID: https://orcid.org/0000-0002-0473-658X)
- Licheng Ju (ORCID: https://orcid.org/0000-0002-3695-6843)
- Claire Liu (ORCID: https://orcid.org/0000-0003-4308-389X)
- Nirbhay N. Yadav (ORCID: https://orcid.org/0000-0003-0802-9791)
- Georg Oeltzschner (ORCID: https://orcid.org/0000-0003-3083-9811)
- Dan Zhu (ORCID: https://orcid.org/0000-0002-0940-1519)
- Kevin Xie (ORCID: https://orcid.org/0000-0001-9210-1201)
- Jiadi Xu (ORCID: https://orcid.org/0000-0001-9698-5622)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Guanshu Liu (ORCID: https://orcid.org/0000-0002-8188-4332)
- Feng Xu (ORCID: https://orcid.org/0000-0001-7958-3787)
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Hye‐Young Heo (ORCID: https://orcid.org/0000-0002-7297-2015)
- Kexin Wang (ORCID: https://orcid.org/0000-0003-0124-0631)
- Qin Qin (ORCID: https://orcid.org/0000-0002-6432-2944)
- Anna Li
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4461
- Primary Topic
- Nuclear Physics and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00