Measuring CSF net velocity using DENSE at 7T with improved correction for involuntary motion and eddy currents.

Motivation: Clearance is important for healthy brain functioning. The ability to measure CSF net velocity would be valuable to gain insight into the underlying mechanisms and pathways of clearance. Goal(s): To measure CSF net velocities in FH and RL direction whilst accounting for periodic motions, involuntary head motion and eddy currents. Approach: A multi-slice single shot DENSE acquisition is used to measure CSF displacements over time. Results: The measured net velocity does not fit the classical view on CSF excretion and absorption locations. Further validation is needed using a moving flow phantom. Impact: The measured net velocities are about 10 percent of what would be expected. If confirmed in a larger cohort, the results challenge the classical view of main CSF excretion at the choroid plexus and absorption at the sagittal sinus.