Detective Ability of pH in Osteosarcoma Microenvironment Using Chemical Exchange Saturation Transfer(CEST) Imaging

Motivation: The precise assessment of the efficacy of preoperative neoadjuvant chemotherapy in osteosarcoma is important for clinical decision making, which requires the consideration of complex factors. Goal(s): In this study, we investigated the ability of ioversol chemical exchange saturation transfer (CEST) imaging in detecting pH in the microenvironment of rat osteosarcoma. Approach: Assessing pH in the microenvironment of osteosarcoma using CEST imaging. Results: It was found that the lower pH value, the lower ratiometric value acquired by two different saturation power of 1μT and 3μT. Impact: In addition, CEST can detect the pH-dependent ratiometric value of tumor microenvironment non-invasively and sensitively. It is expected to become one of the methods for early evaluation of the effect of preoperative neoadjuvant chemotherapy in cancer patients.