Increased brain entropy and its association with cognitive function following mild traumatic brain injury

Motivation: Mild traumatic brain injury (mTBI) is a prevalent neurological condition involved with physical, cognitive, and emotional impairments. Brain dynamics measured with sample entropy and its association with cognitive functions in mTBI patients remains unexplored. Goal(s): We aim to investigate brain entropy changes in mTBI as compared to non-TBI control patients and explore their potential associations with cognitive function in mTBI patients. Approach: Brain entropy mapping was applied based on rs-fMRI images. Results: Results show hyper-entropy within hippocampus and para-hippocampal gyrus which has significant negative association with cognitive scores related to working memory and processing speed. Impact: This study underscores the promise of brain entropy analysis as a valuable addition to mTBI research, with implications for improved diagnostic and treatment strategies.