Risk prediction and postoperative recurrence of Macrotrabecular-Massive Subtype of Hepatocellular Carcinoma based on LI-RADS v2018

Motivation: Macrotrabecular-Massive Subtype of Hepatocellular Carcinoma (MTM-HCC) has been confirmed to possess higher invasiveness and malignancy. Goal(s): This study aims to compare the clinical parameters and imaging characteristics between MTM-HCC and non-MTM-HCC patients, construct a predictive model for the MTM-HCC subtype, and evaluate the model's value in risk stratification. Approach: This study is a retrospective research. Results: The ≥ 50% AP hypovascular component and peritumoral hypointensity on HBP images are independent predictive factors for diagnosing MTM-HCC, and the predictive model exhibits a significant difference in overall recurrence-free survival (RFS) and early recurrence (P < 0.05). Impact: This study, based on the significant imaging features of LI-RADS v2018 and other imaging signs, offers clinical value for the diagnosis and prognosis prediction of the MTM-HCC pathological subtype, providing new insights for the personalized treatment of HCC patients.