Fibrous cap status, plaque surface morphology, and intraplaque hemorrhage volume over two years in patients with carotid plaques: PARISK study

Motivation: We explored the relationship between intraplaque hemorrhage (IPH) and thin/ruptured fibrous cap (TRFC) or disrupted plaque surface. Goal(s): We investigated the relationship between a TRFC/disrupted plaque surface and the change in carotid IPH volumeApproach: Longitudinal carotid MR study in 110 symptomatic patients with mild-to-moderate carotid stenosis. Results: Baseline MR images revealed a larger IPH volume in patients with a TRFC/disrupted plaque surface and the IPH volume (tended to) decrease during follow-up. However, part of patients with a TRFC/disrupted plaque surface at baseline had a higher risk of IPH progression. Impact: Identifying patients at higher risk of IPH progression allows for timely monitoring and intervention, potentially reducing the incidence of stroke. This research contributes to improved quality of life for individuals at risk of carotid IPH-related complications