Right ventricular electromechanical discoordination predict long-term clinical outcomes in patients with pulmonary arterial hypertension

Motivation: Non-invasive and accurate evaluation of right ventricular (RV) function in pulmonary arterial hypertension (PAH) is of urgent need in clinical practice. Goal(s): To investigate the clinical implications of RV electromechanical dyssynchrony which were non-invasively derived from cardiac MRI. Approach: Calculate systolic stretch fraction (SSF) and diastolic relaxation fraction (DRF) based on strain MRI and test their prognostic values in an observation prospective PAH cohort. Results: SSF-RV-Longitudinal could independently predict the clinical worsening. Impact: The present study first reported SSF-RV-Longitudinal as a novel parameter to evaluate RV function, which could predict the clinical worsening in PAH patients.