High-Resolution Diffusion-MRI Detects Accelerated White Matter Degeneration in Alzheimer's Mice after Neurotrauma
Motivation: It is important to understand how neurotrauma accelerates the progression of Alzheimer's disease. Goal(s): The project's goal is to use ultra-high isotropic resolution (60μm) diffusion-MRI for exploring changes in white matter integrity after neurotrauma. Approach: Ex vivo diffusion-MRI was acquired using a 9.4T Bruker scanner in a transgenic mouse model of Alzheimer's disease with and without neurotrauma. Results: We observed decreased quantitative anisotropy in mice 8 months post the brain injury. Impact: Our preliminary finding demonstrated that neurotrauma can induce accelerated white matter degeneration in Alzheimer's disease.
Authors
- Olga Minaeva (ORCID: https://orcid.org/0000-0002-7911-6510)
- Hernán Jara (ORCID: https://orcid.org/0000-0001-6395-3819)
- Juliet A. Moncaster (ORCID: https://orcid.org/0000-0002-7849-4325)
- Lee E. Goldstein (ORCID: https://orcid.org/0000-0001-8419-9800)
- D. Parsons (ORCID: https://orcid.org/0000-0001-6553-0262)
- Ning Hua (ORCID: https://orcid.org/0000-0002-8549-3056)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1611
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00