Altered dynamic functional connectivity and flexibility in type 2 diabetes patients without cognitive decline.

Motivation: The dynamic interaction of time changes in the brain to explore the role of T2DM in brain damage and cognitive decline. Goal(s): To investigate how the dynamic network reconfiguration in T2DM patients and the effect of abnormal blood glucose on the internal network of the brain. Approach: Dynamic functional connectivity analyses and multi-layer network analysis were performed to evaluate the nodal flexibility, network stability and temporal variability of network efficiency. Results: The capability to communicate within or between functional networks connectivity and flexibility are impaired in T2DM and linked to blood glucose levels. Impact: This study is the first to investigate brain injury in T2DM patients by integrating dynamic connectivity and topological features. Dynamic functional connectivity could be a useful imaging biomarker to monitor cognitive changes in T2DM in the future.