Predictive value of DCE-MR perfusion parameters for microsatellite instability in colorectal cancer

Motivation: To find an imaging method that can evaluate microsatellite status of colorectal cancer (CRC). Goal(s): To investigate the value of DCE-MR perfusion parameters and ADC in predicting microsatellite instability of CRC. Approach: DCE-MR perfusion parameters, including Ktrans, Ve, kep, iAUC and ADC were compared between microsatellite instability (MSI) and microsatellite stability (MSS) CRC groups. Receiver operating characteristics (ROC) curve was drawn to evaluate diagnostic efficacy. Results: Univariable analysis revealed that kep had highest diagnostic accuracy (AUC, 0.890; sensitivity, 76.4%; specificity, 90.9%). The diagnostic accuracy of kep combined ADC was the greatest in multivariable analysis (AUC, 0.970; sensitivity, 90.0%; specificity, 100%). Impact: The combination of DCE-MRI based kep value and DWI based ADC value can provide excellent diagnostic accuracy in non-invasively predicting microsatellite status. This study provides insight into potential application of multi-modality MRI in predicting patient with CRC.