Reduced gadolinium dose by an optimized multi-parametric MR-STAT protocol

Motivation: Several concerns have been raised about the harmful effects of gadolinium-based contrast agent (GBCA) usage during MRI exams. Goal(s): To reduce the GBCA dose in MRI protocols. Approach: We developed an optimized and fast MR-STAT protocol for “pre- and post-injection” quantitative MRI and applied it to two retrospective simulated patient datasets and one prospective in-vivo scan. Results: The inferred lesion masks generated by comparing “pre- and post-injection” T1 maps demonstrated that the proposed relaxometry-based method was able to correctly detect the lesions. Furthermore, the performance for the low-dose protocol was comparable to that of the full-dose one. Impact: The quantification of T1 changes after administering GBCA by using the accelerated MR-STAT protocol potentially enables a substantial reduction in both GBCA dose and acquisition time in clinical protocols.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2024-11-26
DOI
https://doi.org/10.58530/2024/0148
Primary Topic
Advanced MRI Techniques and Applications
Type
article
Field-Weighted Citation Impact
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article

Reduced gadolinium dose by an optimized multi-parametric MR-STAT protocol

Anja G. van der Kolk, Miha Fuderer, Jan Willem Dankbaar, Cornelis A. T. van den Berg et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Advanced MRI Techniques and Applications
article

Reduced gadolinium dose by an optimized multi-parametric MR-STAT protocol

Anja G. van der Kolk, Miha Fuderer, Jan Willem Dankbaar, Cornelis A. T. van den Berg, Stefano Mandija, Vera C. Keil, Tom J. Snijders, Alessandro Sbrizzi, Sarah Jacobs, Edwin Versteeg, Oscar van den Heide, Hongyan Liu, Fei Xu
article en

Abstract

Motivation: Several concerns have been raised about the harmful effects of gadolinium-based contrast agent (GBCA) usage during MRI exams. Goal(s): To reduce the GBCA dose in MRI protocols. Approach: We developed an optimized and fast MR-STAT protocol for “pre- and post-injection” quantitative MRI and applied it to two retrospective simulated patient datasets and one prospective in-vivo scan. Results: The inferred lesion masks generated by comparing “pre- and post-injection” T1 maps demonstrated that the proposed relaxometry-based method was able to correctly detect the lesions. Furthermore, the performance for the low-dose protocol was comparable to that of the full-dose one. Impact: The quantification of T1 changes after administering GBCA by using the accelerated MR-STAT protocol potentially enables a substantial reduction in both GBCA dose and acquisition time in clinical protocols.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 63%
Advanced MRI Techniques and Applications
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