Correlation of cerebrovascular reactivity (CVR) with baseline CBF, OEF, and CMRO2

Motivation: Positive correlations between baseline cerebral blood flow (CBF) and BOLD-cerebrovascular reactivity (CVR), both between- and within-subjects were reported. However, there are no studies showing the correlation between CVR and other physiological parameters such as oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2). Goal(s): In this study, these baseline parameters were measured using MRI, and the correlations between CVR and baseline CBF, OEF and CMRO2 were investigated. Approach: Arterial spin labeling and quantitative BOLD were performed to quantify CBF and OEF. Results: Positive correlations between CBF and CVR, CMRO2 and CVR were found. Negative correlation between OEF and CVR was found. Impact: This study presents the correlation of CVR in healthy brain with baseline CBF, OEF, and CMRO2. Positive correlations between CBF and CVR, CMRO2 and CVR were found. Negative correlation between OEF and CVR was also found.