Synthesis and Evaluation of Porphyrin-Based Gadolinium complex as Multifunctional Theranostic Agent

Motivation: Currently used Neutron capture therapy agents in clinic have low tumor targeting ability and have different structures from imaging agents that can view bio-distribution, making it difficult to determine the exact distribution of the drug in the human body. Goal(s): Development of a new MR-image guided drugs for neutron capture therapyApproach: Two of gadolinium complexes of porphyrin derivative were designed and synthesized. Cell uptake study was performed using normal cell and glioblastoma cells. In vivo MR images and ex vivo fluorescence images were obtained. Results: We found that Gd-complexes could enter into the nucleus and be further uptaken by tumor tissues. Impact: Using the two gadolinium complexes, it is possible to compare the therapeutic efficacy of GdNCT and BNCT and expect a synergistic effect. The development of NCT treatments using small molecule substances may have the potential for clinical application.