Saturated T2 Curves for Relaxation-Based Compartmental Analysis in PRESS Localized 1H MRS

Motivation: Rapid Relaxometry through Acquisition of Multiple Saturated T2 Curves (RRAMSC) is a time-efficient STEAM compartmental analysis method. While it has been theorized that the technique can also be used in PRESS localization, it has not yet been demonstrated. Goal(s): Our goal is to examine RRAMSC for separating the tissue water and CSF when using PRESS localized spectroscopy. Approach: To our knowledge, this is the first study to demonstrate the applicability of RRAMSC for PRESS in vivo. Results: Results show excellent agreement between theoretical and actual differences for a PRESS-based RRAMSC, showing negligible differences and a mean error of less than 2%Impact: This study extends the rapid relaxometry through acquistion of multiple saturated T2 curves, a time-efficient relaxometry technique for water compartmentalization, to the more commonly used point resolved spectroscopy localization technique.