Characterization of Radiation Response of Muscular Tissue of the Head and Neck using Quantitative Magnetic Resonance Relaxometry
Motivation: Due to limited options for early monitoring and interventions, radiation therapy (RT) for head and neck cancer patients often leads to dysphagia following treatment due to fibrosis development in swallowing muscles. Goal(s): The goal of this work is to report findings from a retrospective cohort who received RT treatment and longitudinal T1/T2 map imaging. Approach: Evaluating at pre-, mid-, post-, and late- RT allows for statistical analysis of changes in median T1/T2 values. Results: Our hypothesis was confirmed that kinetics are discernable for T1 only, but limited correlation to dose and objective measures of muscle damage was seen in various structures. Impact: At present, there exists no option for the early monitoring of injury from radiation therapy of swallowing muscles related to dysphagia. The aim of this work is to investigate Quantitative MR Relaxometry as a method to monitor for iatrogenic injury.
Authors
- Travis C. Salzillo (ORCID: https://orcid.org/0000-0001-6271-9879)
- Renjie He (ORCID: https://orcid.org/0000-0001-9166-6286)
- Zaphanlene Kaffey (ORCID: https://orcid.org/0009-0008-7999-5245)
- Natalie West (ORCID: https://orcid.org/0009-0007-0211-8845)
- Katherine A. Hutcheson (ORCID: https://orcid.org/0000-0003-3710-5706)
- Mohamed A. Naser (ORCID: https://orcid.org/0000-0003-1020-4966)
- Clifton D. Fuller (ORCID: https://orcid.org/0000-0002-5264-3994)
- Lucas McCullum (ORCID: https://orcid.org/0000-0001-9788-7987)
- Brigid A. McDonald (ORCID: https://orcid.org/0000-0003-4230-1330)
- Yao Ding (ORCID: https://orcid.org/0000-0002-0559-5846)
- Samuel L. Mulder (ORCID: https://orcid.org/0000-0001-5185-4805)
- Abdallah Mohamed (ORCID: https://orcid.org/0000-0003-2064-7613)
- Jihong Wang (ORCID: https://orcid.org/0000-0003-0073-7443)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2171
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00