Evaluation of the glymphatic system activity during sleep-wake states through quantitative CSF measurement using a three-pool water model

Motivation: The glymphatic system plays a crucial role in brain waste clearance, and dysfunction has been linked to neurodegenerative diseases like Alzheimer's Disease. Understanding this system is essential for advancing our knowledge of brain health. Goal(s): We aim to develop a non-invasive method to assess glymphatic activity in the human brain. Approach: We utilize a quantitative CSF measurement technique with a three-pool model and multi-echo spin-echo images. Results: Significant variations in glymphatic activity were observed across different brain regions and found to be influenced by sleep. Impact: Our method can potentially reveal sleep-influenced glymphatic activity variations, enabling early Alzheimer's Disease diagnosis.