AwakeRodent, the multi-center, multi-species, multi-modality study!
Motivation: To bring awareness on the heterogeneity in awake rodent functional imaging. We aim to identify protocol differences that optimize awake functional connectivity, reproducibility and collaboration. Goal(s): To aggregate awake rodent functional datasets, establish population parameters, provide evidence-based recommendations, compare functional Magnetic Resonance Imaging and functional Ultrasound, foster collaborations. Approach: We collect datasets from mice and rats, preprocess and run a seed-based analysis at the individual-level using RABIES. Group-level analysis is performed in Python, resulting in functional connectivity specificity maps. Results: We have gathered 5 mice-datasets and 4 rat-datasets totaling 122 scans with great variability in rodent characteristics, imaging methods, and experimental designs. Impact: Findings will empower researchers to refine awake rodent functional imaging, enhancing investigations into cognitive and behavioral processes, without the anesthesia confounds. This approach closely parallels human brain imaging, enhancing translational relevance and providing an accurate representation of conscious brain function.
Authors
- Mengchao Pei
- A. Elizabeth de Guzman (ORCID: https://orcid.org/0000-0001-6675-4014)
- Garth J. Thompson (ORCID: https://orcid.org/0000-0002-1125-0799)
- Jaakko Paasonen (ORCID: https://orcid.org/0000-0002-1529-596X)
- Zhiwei Ma (ORCID: https://orcid.org/0000-0003-2928-402X)
- Liesbeth Reneman (ORCID: https://orcid.org/0000-0002-5912-9971)
- Binshi Bo
- Petteri Stenroos (ORCID: https://orcid.org/0000-0002-4733-5014)
- Xiuming Tian (ORCID: https://orcid.org/0009-0002-9244-3660)
- Daphne M. P. Naessens (ORCID: https://orcid.org/0000-0001-7898-2559)
- Qikai Qin (ORCID: https://orcid.org/0000-0002-8826-5171)
- Zhifeng Liang (ORCID: https://orcid.org/0000-0003-2758-1194)
- Ruoming Wang
- H. J. Li (ORCID: https://orcid.org/0009-0004-0587-9947)
- Gustav J. Strijkers (ORCID: https://orcid.org/0000-0001-6700-5058)
- Andrea Moreno (ORCID: https://orcid.org/0000-0001-7348-872X)
- Olli Gröhn (ORCID: https://orcid.org/0000-0003-1372-1651)
- Lenka Dvořáková (ORCID: https://orcid.org/0000-0003-0880-4743)
- Bram F. Coolen (ORCID: https://orcid.org/0000-0003-3946-653X)
- Alessandro Gozzi (ORCID: https://orcid.org/0000-0002-5731-4137)
- Santiago Canals (ORCID: https://orcid.org/0000-0003-2175-8139)
- Daniel Gutierrez‐Barragan (ORCID: https://orcid.org/0000-0002-7116-4710)
- Joanes Grandjean (ORCID: https://orcid.org/0000-0001-8413-0491)
- Lindy K. Alles
- Roël M. Vrooman (ORCID: https://orcid.org/0000-0002-2859-6681)
- Alejandro Trouvé-Carpena
- Mengyang Xu (ORCID: https://orcid.org/0000-0003-1346-1191)
- Qian Chen (ORCID: https://orcid.org/0000-0002-0026-2380)
- Marie E Galteau
- Alejandro Sempere-Ferràndez
- Luis Tuset-Sanchis
- Andrew Hayward
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3322
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.34