Amide proton transfer weighted imaging histogram analysis for Prostate Cancer Detection Comparison with Mp-MRI: A two center prospective study

Motivation: The diagnostic utility of whole tumor amide proton transfer–weighted (APTw) imaging analysis for predicting prostate cancer(PCa) has not been reported. Goal(s): The purpose of this study was to evaluate the diagnostic performance of whole tumor APTw histogram analysis, for the depiction of PCa compared with multiparametric MRI with Prostate Imaging Reporting and Data System (PI-RADS) version 2.1. Approach: Diagnostic performance was assessed by ROC with AUC analysis. Results: We found that combining PI-RADS version 2.1 and APTw histogram achieved the best results in distinguishing transition zone PCa from benign prostatic hyperplasia and peripheral zone PCa from chronic prostatitis. Impact: Whole-tumor histogram analysis of APTw images improved the diagnostic performance of multiparametric MRI with PI-RADS version 2.1 in detecting prostate cancer in both the peripheral and transition zones.