Quantitative Imaging Report Framework for the Cleveland Alzheimer’s Disease Research Center (CADRC) Neuroimaging Core (NIC)

Motivation: We have developed an approach to provide a quantitative summary of regional brain measures from an advanced imaging protocol in AD and ADRD subjects as part of the CADRC’s Neuroimaging Core. Goal(s): To establish a panel of advanced imaging markers that will supplement data acquired by the ADRC network. Approach: Structural, functional and quantitative imaging has been implemented, along with procedures for quality assurance and summary outcome measures. Results: 86 subjects have been scanned to date, including those with normal cognition, mild cognitive impairment (MCI) and dementia. Subtypes of impairment include typical and atypical AD, dementia with lewy bodies (DLB). Impact: Although AD is the most common cause of dementia, related and overlapping dementias are common. An inclusive approach to both recruitment and imaging have been implemented to explore new tools for informing patient care in dementia.