High-Resolution Quantitative T2 and T1 Mapping of the Hippocampus

Motivation: The hippocampus is important in memory and is an early target in neurodegenerative diseases. Structural MRI may lack sensitivity to microstructural changes in this region, necessitating more quantitative techniques. Goal(s): We evaluate reproducibility of new radial MRI methods for T2/T1 mapping in the brain and examine age-related changes. Approach: Quantitative maps were generated using novel pulse sequences and reconstruction algorithms. We assessed reproducibility and age-related trends. Results: We observed strong correlations in T2 and T1 measurements between imaging sessions. We observed positive relationships between T2 and T1 measurements and age in white matter and negative relationships in gray matter regions. Impact: This study introduces novel radial MRI techniques for mapping of the brain and hippocampus, with potential to offer insights into early neurodegenerative changes. Findings on reproducibility and age-related trends contribute to improved understanding of brain health and potential diagnostic applications.