Amide proton transfer weighted imaging and diffusion kurtosis imaging in differentiating breast lesions by comparing with BI-RADS

Motivation: Breast Imaging Reporting and Data System (BI-RADS) is an internationally recognized scoring standard for the diagnosis of breast lesions, but it is highly subjective. Goal(s): To evaluate the diagnostic performance of amide proton transfer weighted imaging (APTWI) and diffusion kurtosis imaging (DKI) in terms of differentiating breast lesions and to compare them with the BI-RADS independently or jointly. Approach: Prospective cohort studyResults: APTWI and DKI can be used to distinguish breast lesions. The combination with APTWI and DKI can significantly improve the AUC values and specificity when compared with BI-RADS alone. The APTWI+DKI+BI-RADS has the best diagnostic performance in distinguishing breast lesions. Impact: The combined APTWI and DKI outperformed BI-RADS alone in distinguishing benign and malignant breast lesions.