Comparison of fast quantitative magnetization transfer imaging methods on a 1.5 T MR-Linac
Motivation: Quantitative magnetization transfer (qMT) could guide radiotherapy on MRI-linear accelerators (MR-Linacs), but limited scan time requires a fast sequence. Fast 3D qMT is possible with balanced steady-state free precession (bSSFP) or echo-planar imaging (EPI), but which method is superior is unclear. Goal(s): Our goal was to determine whether bSSFP or EPI qMT on a 1.5T MR-Linac was best for imaging glioblastoma patients. Approach: Eight patients were scanned using both methods. Repeatability in normal tissue and magnitude of tumor changes were compared. Results: A 2 minute 20 second EPI qMT scan was more repeatable than bSSFP qMT and detected greater tumor changes. Impact: The improvement in quantitative magnetization transfer acquisition speed through using 3D EPI enables integration into MR-Linac radiotherapy workflows, an unmet need as qMT can detect white matter changes which could be used to assess tumor response during treatment.
Authors
- Angus Lau (ORCID: https://orcid.org/0000-0002-9604-394X)
- Arjun Sahgal (ORCID: https://orcid.org/0000-0001-7991-8970)
- Liam Lawrence (ORCID: https://orcid.org/0000-0003-2070-8308)
- Pejman Maralani (ORCID: https://orcid.org/0000-0001-9975-4379)
- Jay Detsky (ORCID: https://orcid.org/0000-0002-0117-6839)
- Hany Soliman (ORCID: https://orcid.org/0000-0003-2824-2100)
- Sten Myrehaug (ORCID: https://orcid.org/0000-0002-5765-1969)
- Mark Ruschin
- Rachel W. Chan (ORCID: https://orcid.org/0000-0003-0475-1111)
- Aimee Theriault
- Brandon Tran (ORCID: https://orcid.org/0000-0003-0436-551X)
- Chia‐Lin Tseng (ORCID: https://orcid.org/0000-0002-3700-0886)
- James Stewart (ORCID: https://orcid.org/0000-0002-3134-3415)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4465
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00