Rotational flow as a marker of left ventricular function between youth and adult T2D subjects

Motivation: Rotational flow within the aorta has been associated with cardiovascular disease and ventricular-vascular coupling, but no study has investigated its direct correlation with LV function. Goal(s): This study aims to explore whether the assessment of rotational flow can effectively identify left ventricle dysfunction between youth and adult type 2 diabetes (T2D) subjects. Approach: Correlation between global function and strain changes by CMR and rotational flow indices and pulse wave velocity by 4D flow MRI were evaluated. Results: Adult T2D had significant decrease in vorticity indices with CMR biomarkers, while showing less significance in CMR biomarkers compared to youth T2D. Impact: Vorticity indices are potential biomarkers to assess LV dysfunction and understand ventricular-vascular coupling even in the absence of geometric anomalies within the aorta. A comprehensive examination of rotational flow and LV function is required.