Evaluation of liver function using Gd-EOB-DTPA-enhanced MRI by B1-corrected VFA T1 mapping method

Motivation: There is a lack of suitable tools for monitoring liver function to determine the optimal treatment strategy for patients. Goal(s): To evaluate the value of B1-corrected VFA T1 mapping in predicting liver function. Approach: T1 relaxation time at corresponding time-points in B1-corrected VFA T1 mapping were measured. We analyzed the correlation of T1 value with indocyanine green retention rate at 15min (ICG-R15) and conducted Receiver operating characteristic (ROC) to evaluate the albumin-bilirubin (ALBI) grade classification efficiency by T1 mapping parameters. Results: T1-10min, T1-HBP and △T1% showed moderate correlation with ICG-R15. T1-5min had the best diagnostic efficacy in differentiating ALBI 1 and ALBI 2. Impact: This study explored that T1 value of Gd-EOB-DTPA-enhanced MRI by B1-corrected VFA method can be used as noninvasive imaging indicators for estimation of liver function.