Memory impairment is associated with glymphatic dysfunction in hemodialysis patients

Motivation: Glymphatic function assessed by diffusion tensor image analysis along the perivascular space (DTI-ALPS) index might be associated with cognitive function. Goal(s): To examine the glymphatic function in patients who receive regular hemodialysis and its relationship with clinical indices. Approach: Partial correlation analysis was applied to assess the relationship between ALPS index and clinical markers with age and sex as covariates. Results: Left ALPS index is positively correlated with immediate recall scores after adjusting for age and gender. Impact: Glymphatic function and hemoglobin levels are associated with memory dysfunction in hemodialysis patients, offering a potential way to improve memory function in this population.