Radiomics of voxelwise DCE-MRI TIC profiles map enables quantifying temporal and spatial hemodynamic heterogeneity in breast lesions

Motivation: An effective approach that enables simultaneous quantification of spatial and temporal heterogeneity based on DCE-MRI is lacking. Goal(s): To develop a data-driven model-free approach to quantify spatial and temporal hemodynamic heterogeneity. Approach: We introduced radiomics analysis based on voxelwise mapping of DCE-MRI time-intensity-curve (TIC) profiles to quantify temporal and spatial hemodynamic heterogeneity and investigated its value in differentiating malignant and benign breast lesions. Results: Radiomics features and composition ratio of voxelwise TIC profiles showed good performance in differentiating malignant and benign breast lesions. Impact: We provide a novel data-driven model-free approach for visualizing and quantifying temporal and spatial hemodynamic heterogeneity simultaneously, which shows potential for a variety of clinical implications concerning individualized management of breast lesions.