Manganese-based nanoparticles for 1H/19F MRI and immune-activated co-therapy for tumor microenvironment response

Motivation: Simultaneous enhancing MRI signals and effectively generating and activating immune cells is a significant challenge when using one contrast agent. Goal(s): This work aims to develop nanoparticles of guiding tumor synergistic therapy using 1H/19F MRI while activating the STING pathway. Approach: FMBI nanoparticles were designed for enhancement of 1H/19F MRI and activation of the immune system. Results: FMBI nanoparticles responsively release Mn ions in the tumor microenvironment to enhance the signals of 1H/19F MRI and improve immune pathway activity and anti-tumor efficacy. Impact: Our synthesized FMBI nanoparticles are a STING pathway-activatable contrast agent that can be used for 1H/19F MRI-guided tumor therapy with high efficacy, which shows promise for effective tumor immunotherapy.