Multi-B-Values-Fitting RESOLVE DWI in Evaluation of Disease Activity and Curative Effect of Axial Spondyloarthritis (axSpA)

Motivation: Methods to quantitatively assess disease activity and efficacy of axSpA are still being explored. Goal(s): To find a reliable quantitative indicator for evaluating disease activity and curative effect of axSpA, using multi-b-values-fitting RESOLVE DWI. Approach: By comparing the ADC values calculated by fitting different b values between different groups, a relatively reliable b-values-fitting sequence was obtained, further evaluating curative effect of the treatment group in different cycles. Results: Multi-b-values-fitting (b=50,500,700s/mm2) RESOLVE DWI has a certain advantage in evaluating disease activity and efficacy of axSpA, but the effect of short-term review (3 weeks or less) is unsatisfactory. Impact: Multi-b-Values-Fitting RESOLVE DWI can differentiate the severity of axSpA disease activity more intuitively, by measuring the ADC values of bone marrow edema of sacroiliac joints, providing a new idea for clinical search for more objective and accurate quantitative parameters.