A Novel Approach for Simultaneous T1, T2, T2*, and Proton Density Mapping via Longitudinal Magnetization Control MOLED Acquisition

Motivation: Traditional multi-parameter mapping methods use different sequences to acquire images with varying TE or TI, posing challenges like registration, time consumption, and physiological asynchrony among parameters. Goal(s): To rapid acquire self-registered multi-parametric maps. Approach: A longitudinal magnetization control multiple overlapping-echo detachment (LMC-MOLED) imaging method was proposed. In the first phase of LMC-MOLED, T2-T2*-MOLED was acquired using the blip-up blip-down SE-EPI/GRE-EPI readout. Subsequently, after five T2-MOLED acquisitions were applied with varying delay intervals, MOLED images with distinct T1 weighting were captured. Results: LMC-MOLED can simultaneously acquire five slices of multi-parametric maps, including T1, T2, T2*, PD, ΔB0, and B1, within 5.5 s. Impact: LMC-MOLED is a novel and rapid simultaneous multi-parameter magnetic resonance quantitative method that may aid in the clinical diagnosis of diseases such as multiple sclerosis and tumors.