Layer-fMRI in lower brain structures: why is it so hard and what can we do about it?
Motivation: Layer-fMRI can address questions of directional information flow, but it’s difficult in lower brain areas. Goal(s): We want to make layer-fMRI work in low brain structures, despite commonly low tSNR, EPI distortions, and EPI phase errors. Approach: We tested the efficacy of four advanced acquisition approaches to mitigate these challenges: pTx, dual-polarity readouts, multi-shot segmentation, and aggressive GRAPPA. Results: We found that pTx and high GRAPPA had limited impact for improved image quality. Though, multi-shot segmentation and dual-polarity readouts allowed layer-fMRI applications in low brain areas. Impact: This work helps to fulfill the promise of layer-fMRI beyond the top 50% of the cortex.
Authors
- Susan G. Wardle (ORCID: https://orcid.org/0000-0003-2216-7461)
- Andrew S. Persichetti (ORCID: https://orcid.org/0000-0002-1580-8497)
- Rüdiger Stirnberg (ORCID: https://orcid.org/0000-0001-7021-1063)
- Peter A. Bandettini (ORCID: https://orcid.org/0000-0001-9038-4746)
- Philipp Ehses (ORCID: https://orcid.org/0000-0002-5839-6525)
- Kenshu Koiso (ORCID: https://orcid.org/0000-0001-5931-6294)
- Anne-Marie Morgan (ORCID: https://orcid.org/0000-0001-9486-5555)
- Laurentius Huber (ORCID: https://orcid.org/0000-0002-3291-2202)
- Chung Kan
- Nadine Graedel
- Isabel Gephart
- Sam Audrain
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3129
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00