Microvascular invasion-negative hepatocellular carcinoma: prognostic value of qualitative and quantitative Gd-EOB-DTPA MRI analysis

Motivation: To explore the prognostic parameters related to microvascular invasion (MVI)-negative HCC patients. Goal(s): The aim of this study was to establish a model for predicting the prognosis of patients with MVI-negative HCC based on qualitative and quantitative analyses of Gd-EOB-DTPA MRI. Approach: Totally, 122 patients were retrospectively enrolled. Multivariate logistic regression analysis was performed to identify significant clinical parameters, and quantitative and qualitative MRI parameters associated with prognosis. Results: Multivariate analysis showed that lower RER, HBP hypointensity without APHE, LI-RADS category, mild-moderate T2 hyperintensity, and higher AST levels were risk factors associated with prognosis. The most appropriate threshold value for RER was 1.197. Impact: The nomogram incorporated preoperative qualitative and quantitative parameters and laboratory indices, namely LI-RADS category, HBP hypointensity without APHE, lower RER, mild-moderate T2 hyperintensity, and higher AST levels, can be a reliable tool for predicting prognosis in patients with MVI-negative HCC.