Changes in Brain Network Connectivity in Obese Patients Following Weight Loss Surgery Based on Independent Component Analysis

Motivation: Bariatric surgery can rapidly alter obese status, but its effects on resting state functional connectivity (rsFC) in obesity remain unclear. Goal(s): We examined the effects of bariatric surgery on rsFC between brain networks in obese patients using independent component analysis. Approach: Thirty obese patients underwent resting state fMRI scans before and after bariatric surgery. We used independent component analysis to analyze surgery-related rsFC changes. Results: Bariatric surgery improved rsFC of hVN-lFPN, hVN-SMN, AUN-pDMN, AUN-DAN, pVN-aDMN, pVN-SMN, pDMN-SN, aDMN-DAN, and SMN-DAN in obese patients. These results indicate that bariatric surgery induces functional reorganization of brain networks in obesity. Impact: Bariatric surgery can rapidly alter obese status. Our study investigates the rsFC before and after bariatric surgery, results show that bariatric surgery induces functional reorganization of brain networks in obesity.