Dynamic 31P MRS Reveals Delayed PCr Depletion and Muscle Fatigue in Association with Exercise Training in Patients with Parkinson’s Disease

Motivation: Parkinson’s disease (PD) is a leading neurodegenerative disorder. Currently there are no medical interventions or medications to slow the progression of PD. Rehabilitation for aerobics, strength and motor control is critical to consider as it ameliorates symptoms, decrease falls, and improves quality of life. However, the metabolic mechanism of rehab is not fully understood. Goal(s): Report evidence that, upon targeted muscle exercise training, the muscle energetics is improved at cellular and molecular level. Approach: PD patients were scanned by 31P MRS before and after a 4-week progressive strengthening program. Results: Upon rehabilitation, PCr decline with exercise is slowed in parallel to delayed fatigue. Impact: The metabolic findings in the present study support the note and practice that strength-focused rehab programs can benefit patients with PD in the management of their weakness and improving quality of life.