Investigating the biomechanical properties of the aging mouse brain using an elastographic atlas
Motivation: The biomechanical signature of the aging brain and its correlation with the underlying microstructure, is poorly understood. Goal(s): To systematically analyze the global and regional biomechanical properties of the brain during aging. Approach: We investigated the in vivo biomechanical progression of the female mouse brain over an age range of 6 to 18 months using multifrequency MR elastography. Results: Highly resolved elastographic atlases of the mouse brain at different ages were generated. Global and regional analysis revealed softening and reduced viscosity as dominating patters of biomechanical changes related to the structural variations of the aging brain. Impact: This study demonstrated the use of MR elastography to track the biomechanical changes in the brains of aging healthy mice. Our study revealed softening and increased viscosity as biomechanical signature of the aging brain.
Authors
- Carmen Infante‐Duarte (ORCID: https://orcid.org/0000-0003-3005-351X)
- Jing Guo (ORCID: https://orcid.org/0000-0002-1170-8157)
- Baofu Huang
- Rafaela V. Silva (ORCID: https://orcid.org/0000-0002-8687-2154)
- Tom Meyer (ORCID: https://orcid.org/0000-0002-2171-6791)
- Yasmine Safraou (ORCID: https://orcid.org/0009-0009-7347-1552)
- Ingolf Sack (ORCID: https://orcid.org/0000-0003-2460-1444)
- Jürgen Braun (ORCID: https://orcid.org/0000-0001-5183-7546)
- Anna S. Morr (ORCID: https://orcid.org/0000-0002-0101-1292)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4125
- Primary Topic
- Elasticity and Material Modeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00