To compare the value of intratumoral and peritumoral IVIM and MUSE-IVIM magnetic resonance imaging in predicting of HER-2 status in breast cancer

Motivation: Few studies had explored different diffusion imaging techniques of magnetic resonance imaging for molecular prognostic factors of breast cancer, and human epidermal growth factor receptor-2(HER-2) was closely related to targeted therapy. Goal(s): To compare the effect of high-resolution magnetic resonance intravoxel incoherent motion based on multiplexed sensitivity encoding (MUSE-IVIM) and conventional IVIM in predicting HER-2 status in breast cancer. Approach: Different parameters of MUSE-IVIM and IVIM within and around the tumor were analyzed, including apparent diffusion coefficient (ADC), tissue diffusivity (Dt), pseudo diffusivity (Dp), perfusion fraction (f). Results: IVIM-Dt-intratumoral predicted HER-2 with the highest value(AUC=0.775, P=0.003). Impact: Although the signal to noise ratio (SNR) of MUSE-IVIM was higher than IVIM, they may be evenly matched in predicting HER-2 in breast cancer, which required more research and exploration.