Distinct progression patterns of white matter microstructure in Parkinson’s disease associated with REM sleep behavior disorder
Motivation: Rapid eye movement sleep behavior disorder (RBD) significantly impacts clinical outcomes in Parkinson's disease (PD). Goal(s): Our goal was to investigates the neurophysiological mechanisms related to motor and cognitive decline longitudinally in PD with RBD (PD-RBD). Approach: We used diffusion tensor imaging and clinical assessments on 83 PD patients over 2 years, two groups were formed: PD-RBD and PD without RBD (PD-nonRBD). Results: PD-RBD experienced widespread decline in white matter microstructure which are associated with motor symptoms aggravation, while PD-nonRBD patients showed limited changes. Impact: The presence of RBD suggests more extensive white matter degeneration in PD, particularly affecting motor symptoms.
Authors
- Xiaojie Duanmu
- Xiaojun Guan (ORCID: https://orcid.org/0000-0003-2313-4477)
- Sijia Tan
- Jianmei Qin
- Minming Zhang (ORCID: https://orcid.org/0000-0003-0145-7558)
- Cheng Zhou (ORCID: https://orcid.org/0000-0003-0770-2649)
- Xiaojun Xu (ORCID: https://orcid.org/0000-0002-0127-2812)
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-7164-0764)
- Weijin Yuan
- Jiaqi Wen (ORCID: https://orcid.org/0000-0002-4520-4395)
- Tao Guo (ORCID: https://orcid.org/0000-0003-3724-8686)
- Qianshi Zheng
- Jingwen Chen (ORCID: https://orcid.org/0009-0004-2291-5954)
- Haoting Wu
- Chenqing Wu (ORCID: https://orcid.org/0009-0003-3258-2869)
- Yong Zhang (ORCID: https://orcid.org/0009-0009-7948-512X)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2344
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00