Prognostic Value of Global and Segmental LV Myocardial Strain Parameters Derived from CMR-FT Technique in AL-CA Patients: A Pilot Study.

Motivation: Early detection of cardiac involvement and continuous monitoring of disease progression could benefit patients with light-chain amyloidosis. The application of left ventricular strain by Cardiac magnetic resonance feature tracking imaging has emerged as an excellent noninvasive imaging modality. Goal(s): This study is dedicated to exploring the prognostic implications of myocardial strain in distinct myocardial segments. Approach: The assessment of both global and segmental myocardial strain was conducted through the application of steady-state free precession (SSFP) cine sequences. Results: Global radial strain (RSglobal), RS in the basal lateral segment (RSbas-lateral) and B-type natriuretic peptides (BNP) are independently associated with all-cause mortality. Impact: Quantification of LV strain could be employed to monitor the progression of amyloid light-chain (AL) amyloidosis. Global radial strain and radial strain in the basal lateral segment may prove valuable for risk stratification in patients with AL amyloidosis.