MR fingerprinting for quantification of brain amyloid burden: from development to prospective multi-site external validation
Motivation: A non-invasive amyloid beta (Aβ) imaging technique is needed for objective diagnosis and treatment monitoring of Alzheimer’s disease. Goal(s): To develop and validate an MRF-based method quantifying brain Aβ. Approach: A framework with efficient MRF data acquisition, neural network decoding, and atlas-based segmentation was implemented. A prospective analysis was conducted on external dataset to evaluate its generalizability, repeatability, and correlation with Aβ-PET measurements and clinical cognitive function tests. Results: The method showed high repeatability (CV<2%), significant correlation with Aβ-PET measurements and Montreal Cognitive Assessment test (p=0.015 and 0.020, respectively), and discriminated subject-level Aβ positivity with an AUC of 0.84 on external test set. Impact: The proposed framework is compatible with clinical 3T MRI and offers ‘one-stop’ examination in 10 minutes for patients with cognitive decline by providing structural MRI and Aβ-quantification. Its non-invasive nature facilitates longitudinal evaluation and correlates with Aβ-PET and cognitive function.
Authors
- Kaito Takabayashi (ORCID: https://orcid.org/0000-0002-5562-1504)
- Issei Fukunaga (ORCID: https://orcid.org/0000-0003-2423-2685)
- Koji Murakami (ORCID: https://orcid.org/0000-0002-3745-4650)
- Koji Kamagata
- Madoka Nakajima (ORCID: https://orcid.org/0000-0002-8496-2973)
- Atsushi Shima (ORCID: https://orcid.org/0000-0002-3068-4621)
- Yujiro Otsuka (ORCID: https://orcid.org/0000-0002-6677-0804)
- Yuji Nakamoto (ORCID: https://orcid.org/0000-0001-5783-8048)
- Shohei Fujita (ORCID: https://orcid.org/0000-0003-4276-6226)
- Mathias Nittka (ORCID: https://orcid.org/0000-0002-3023-0224)
- Yasutaka Fushimi (ORCID: https://orcid.org/0000-0002-1982-3168)
- Manabu Kubota (ORCID: https://orcid.org/0000-0001-9507-1845)
- Gregor Koerzdoerfer (ORCID: https://orcid.org/0000-0002-8881-9517)
- Berkin Bilgic̦ (ORCID: https://orcid.org/0000-0002-9080-7865)
- Nobukatsu Sawamoto (ORCID: https://orcid.org/0000-0001-8695-0223)
- Yumiko Motoi
- Guido Buonincontri (ORCID: https://orcid.org/0000-0002-8386-639X)
- Shigeki Aoki (ORCID: https://orcid.org/0000-0002-8491-0698)
- Katsutoshi Murata (ORCID: https://orcid.org/0000-0003-0615-7116)
- Osamu Abe
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3911
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00