Three-dimensional MR Elastography Identifies Portal Hypertension in Cirrhosis: A Prospective Multicenter Study

Motivation: Hepatic venous pressure gradient (HVPG) is the gold standard for diagnosing portal hypertension, but it is invasiveness, cost, and feasibility. Goal(s): To develop a non-invasive model based on Three-dimensional (3D) MR elastography (3D-MRE) to detect portal hypertension. Approach: Spearman correlation analysis between 3D-MRE parameters and HVPG; Multivariable linear regression analysis between mechanical parameters and HVPG; Logistic regression analysis and establish a model to diagnose portal hypertension. Results: 3D-MRE is a non-invasive, rapid, and highly accurate tool for predicting portal hypertension. Especially Spleen stiffness at 60Hz was the independent parameters associating HVPG. Impact: This indicates that the use of 3D-MRE can provide more personalized evaluation and better medical experience for patients with cirrhosis and provides a new method for non-invasive diagnosis of portal hypertension.