Characteristics of myocardial tissue triglyceride content detected by MRS in Duchenne muscular dystrophy

Motivation: Myocardial fat infiltration is the key pathological features of Duchenne muscular dystrophy associated cardiomyopathy. Magnetic resonance spectroscopy is a valuable method for detecting the in vivo changes of cardiac metabolism noninvasively. Goal(s): To investigate the characteristics of myocardial tissue triglyceride content in DMD by non-invasive MRS. Approach: Twenty patients with DMD and Controls underwent cardiac MRI, including spectral sequence. The peak area and the area under the peak of H2O and TG in each voxel were calculated. The t-test whether the sample mean was significant. Results: The difference of TG content between DMD children normal group and the two groups was statistically significant. Impact: Cardiac magnetic resonance spectrum can reflect myocardial triglyceride relative quantity for myocardial lipid content in the different stages of disease on how to change.