Association of serum uric acid with right cardiac chamber remodeling assessed by CMR-feature tracking in patients with connective tissue disease

Motivation: To explore a common and low-cost indicator in patients with connective tissue disease (CTD) to determine the subclinical right cardiac chamber remodelingGoal(s): Investigated the association of Serum uric acid (SUA) with right cardiac chamber remodeling assessed by cardiac magnetic resonance feature-tracking (CMR-FT) in CTD patients. Approach: All individuals underwent CMR examinations and their SUA levels were recorded. CMR-FT was used to evaluate the right atrial and ventricular strain parameters. Results: CTD patients had significantly right cardiac chamber remodeling and elevated SUA levels compared with controls. SUA may be a potential risk factor of right cardiac chamber remodeling in CTD patients. Impact: Right heart remodeling is widespread in CTD patients. SUA is considered a potential independent risk factor for cardiovascular disease and elevated SUA levels are often observed in CTD patients.