Detection of vasomotion in the human brain using Fourier decomposition of T1-weighted Cine-FLASH MRI (FD-FLASH)

Motivation: Vasomotion has been hypothesized as a mechanism for brain paravascular clearance, which could be impaired in multiple neurodegenerative conditions. Goal(s): To measure vasomotion in vivo in human brains using MRI. Approach: A single-shot T1-weighted Cine-FLASH sequence was optimized to provide high temporal resolution in two adults, as well as during a visual stimulation paradigm in one. We performed a Fourier decomposition of the signal in brain vascular structures. Results: An ultra-low-frequency signal was observed consistent with vasomotion in posterior cerebral arteries while no such signal could be identified in the parenchyma. A substantial amplification of this signal could be observed during visual stimulation. Impact: This method could help studying brain waste clearance and its dysfunction in humans in vivo.