Assessment of Periventricular Gradient of Myelin Content in Multiple Sclerosis Using Synthetic MRI
Motivation: Though periventricular gradient (PVG) mapping has been demonstrated to be useful, previous studies have employed 2D magnetization transfer ratios and T1 maps, which are not specific to myelin. Goal(s): This study investigates the use of synthetic MRI myelin maps to assess the periventricular gradient (PVG) of myelin volume fraction (MVF) in multiple sclerosis (MS) patients. Approach: This study includes 22 healthy individuals, 84 patients with relapsing-remitting MS (RRMS), and 17 patients with secondary progressive MS (SPMS). Results: PVGs of RRMS and SPMS were higher than that of healthy individuals, with SPMS showing higher PVG than RRMS. Impact: In conclusion, the influence of demyelination in MS appears to be more prominent in the vicinity of the ventricles.
Authors
- Akifumi Hagiwara (ORCID: https://orcid.org/0000-0001-5277-3249)
- Nobutaka Hattori (ORCID: https://orcid.org/0000-0002-2034-2556)
- Akihiko Wada (ORCID: https://orcid.org/0000-0003-3432-0267)
- Masaaki Hori (ORCID: https://orcid.org/0000-0002-1791-8032)
- Wataru Uchida
- Christina Andica (ORCID: https://orcid.org/0000-0002-9339-6950)
- Yuji Tomizawa (ORCID: https://orcid.org/0000-0002-5462-6725)
- Towa Sekine (ORCID: https://orcid.org/0009-0009-6450-0104)
- Moto Nakaya (ORCID: https://orcid.org/0000-0001-7697-6286)
- Satoru Kamio
- Koji Kamagata (ORCID: https://orcid.org/0000-0001-5028-218X)
- Shigeki Aoki (ORCID: https://orcid.org/0000-0003-2821-0651)
- Yasunobu Hoshino
- Osamu Abe
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2974
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00