Evaluation of Spin-Echo EPI MR Elastography for Rapid Free-Breathing Quantification of Liver Stiffness
Motivation: Hepatic stiffness (HS), detected by MR elastography (MRE), is a biomarker for hepatic fibrosis. Liver MRE requires breath-holding (BH), which is challenging in children or people with liver disease. Spin-echo echo-planar-imaging (SE-EPI) MRE can quantify HS rapidly(~10 s), even with iron overload. Goal(s): To evaluate free-breathing (FB) SE-EPI MRE without respiratory triggering or motion compensation in terms of agreement, repeatability, and measurable liver area [%] with respect to BH SE-EPI MRE. Approach: BH and FB SE-EPI MRE were acquired in 23 children and 2 adults with liver biopsy. Results: FB SE-EPI MRE provided fast, accurate, and repeatable HS with high measurable liver area. Impact: The free-breathing (FB) MR elastography (MRE) of the liver based on spin-echo echo-planar-imaging (SE-EPI) produced accurate and repeatable hepatic stiffness with respect to standard breath-held SE-EPI MRE. FB SE-EPI MRE can be useful for populations who cannot hold their breath.
Authors
- Shahnaz Ghahremani (ORCID: https://orcid.org/0000-0002-4524-2391)
- Bradley D. Bolster (ORCID: https://orcid.org/0000-0003-1474-0969)
- Timothy Adamos (ORCID: https://orcid.org/0000-0002-9234-039X)
- Kara L. Calkins (ORCID: https://orcid.org/0000-0001-6658-7981)
- Shu‐Fu Shih (ORCID: https://orcid.org/0000-0002-3812-9091)
- Sevgi Gökçe Kafalı (ORCID: https://orcid.org/0000-0001-5941-5399)
- Timoteo Delgado (ORCID: https://orcid.org/0000-0001-6709-410X)
- Holden H. Wu (ORCID: https://orcid.org/0000-0002-2585-5916)
- María I. Altbach (ORCID: https://orcid.org/0000-0001-9368-2458)
- Vibhas Deshpande (ORCID: https://orcid.org/0000-0003-0264-6553)
- David Lu (ORCID: https://orcid.org/0000-0002-3263-4476)
- Seungheon Han (ORCID: https://orcid.org/0009-0008-3230-841X)
- Kevin Johnson (ORCID: https://orcid.org/0000-0002-5938-0154)
- Pedro Itriago Leon
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4796
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00