High Resolution MRI Protocol for Ovarian Cancer Screening

Motivation: Addressing the critical need for improved ovarian cancer detection, given its high mortality rate and limited screening options. Goal(s): Explore diffusion properties of normal ovaries and lesions at high b-values (>1000 s/mm2 to develop a high-resolution ovarian cancer screening (OCS) protocol for average and high-risk individuals. Approach: Utilized multishell diffusion-weighted MRI (DW-MRI) with simultaneous multi-slice excitation (Multiband) to capture high-resolution images in healthy, high-risk BRCA 1/2, and patients with potential cancer based on prior imaging. Results: Distinct abnormal lesion types exhibited distinct contrasts at high b-values, with normal ovaries showing no signal, as expected. Impact: Preliminary ovarian cancer MRI results with multishell DWI with Multiband, show promise in a new screening tool for ovarian cancer screening. This marks a significant step toward non-invasive screening advancements for high-risk individuals and early detection strategies.