Dynamic contrast-enhanced gastric MRI features are related to adverse histopathological status in advanced gastric cancer

Motivation: Distinct histopathological types are closely related to the prognosis of advanced gastric cancer. Adverse histopathological status (AHS) is linked to poor gastric cancer outcomes. Extra-dimensional volumetric interpolated breath-hold examination (XD-VIBE) offers high temporal and spatial resolution while allowing free breathing. Goal(s): To improve the assessment of AHS, we explored the potential for XD-VIBE to improve DCE imaging. Approach: We evaluated the associations of quantitative DCE MRI parameters (e.g., Ktrans, Ve, and Kep) with AHS. Results: Using XD-VIBE, quantitative DCE MRI parameters allowed non-invasive assessment of AHS and helped to optimize treatment strategies for advanced gastric cancer. Impact: In this single-institution study, quantitative DCE MRI features demonstrated promise as markers of AHS in advanced gastric cancer. These features could provide added prognostic value and identify patients who may benefit from adjuvant therapy.