Prediction of Lymphovascular Space Invasion in endometrial cancer using MRI-based radiomics models

Motivation: Predicting LVSI before surgery remains a critical challenge. Goal(s): To predict preoperative LVSI in patients with endometrial cancer in a noninvasive way. Approach: We developed and validated MRI radiomics and clinical-radiomics models based on the features extracted from tumor and peritumoral regions. Results: The clinical-radiomics model based on the features extracted from the tumors with 3mm peritumoral region exhibited the hightest predictive performance in the training cohort and testing cohort with an AUC of 0.86 and 0.86, respectively. The model also displayed clinical validity as depicted in the DCA curve. Impact: Incorporating the radiomics features extracted from tumor with 3mm peritumoral region and clinical significance factors can improve the predictive efficacy of the model for predicting LVSI and increase its applicability in clinical practice.